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Annals of the New York Academy of Sciences, VIP, Pacap, and Related Peptides: From Gene to Therapy

Annals of the New York Academy of Sciences VIP Pacap and Related Peptides From Gene to Therapy This volume provides an overview on the biochemistry physiology and pharmacology of vasoactive intestinal polypeptide VIP pituitary adenylate cyclase activating polypeptide PACAP and related pep

  • Title: Annals of the New York Academy of Sciences, VIP, Pacap, and Related Peptides: From Gene to Therapy
  • Author: Hubert Vaudry Marc Laburthe
  • ISBN: 9781573315500
  • Page: 113
  • Format: Paperback
  • This volume provides an overview on the biochemistry, physiology, and pharmacology of vasoactive intestinal polypeptide VIP , pituitary adenylate cyclase activating polypeptide PACAP , and related peptides VIP and PACAP are undoubtedly among the most fascinating neuropeptides ever identified They belong to the largest family of regulatory peptides, which comprises seveThis volume provides an overview on the biochemistry, physiology, and pharmacology of vasoactive intestinal polypeptide VIP , pituitary adenylate cyclase activating polypeptide PACAP , and related peptides VIP and PACAP are undoubtedly among the most fascinating neuropeptides ever identified They belong to the largest family of regulatory peptides, which comprises several other prominent neuroendocrine peptides including secretin the first peptide hormone that has been identified , glucagon, and growth hormone releasing hormone The structural and physiological relationships of these peptides as well as their receptors provide a unique model for investigating the processes of molecular evolution leading to the diversification of multigene families.The primary structures of VIP and PACAP have been remarkably well conserved across vertebrates, suggesting that these peptides must be involved in vital functions throughout the animal kingdom Indeed, VIP and PACAP appear to be implicated in a large array of physiological processes such as development growth endocrine, cardiovascular, respiratory, reproductive and digestive functions immune responses and circadian rhythms There is also clear evidence that VIP and PACAP exert both trophic and antiproliferative effects on normal and tumor cells The beneficial influence of VIP and PACAP agonists and antagonists in various pathological states including heart failure, ischemia, asthma, impotence, and cancer has motivated the development of novel selective VIP or PACAP ligands that could potentially be used as antihypertensive, neuroprotective, bronchodilatory, vasodilatory, and or antiproliferative drugs The occurrence of multiple VIP PACAP receptor subtypes and splice variants that exhibit tissue specific expression and possess differential affinity for various ligands generates hopes for the development of new therapeutic agents that could act selectively on the desired target cells NOTE Annals volumes are available for sale as individual books or as a journal For information on institutional journal subscriptions, please visit blackwellpublishing nyas ACADEMY MEMBERS Please contact the New York Academy of Sciences directly to place your order nyas Members of the New York Academy of Science receive full text access to the Annals online and discounts on print volumes Please visit http nyas MemberCenter Joinpx for information about becoming a member.

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    1. Hubert Vaudry Marc Laburthe

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